Korthals J K, Korthals M A, Wisniewski H M
James A. Haley Veterans' Hospital, Tampa, FL.
Brain Res. 1991 Jun 21;552(1):41-6. doi: 10.1016/0006-8993(91)90657-h.
We performed morphologic studies on the progression of regeneration in cat hind limb nerves after acute ischemic injury. None of the damaged nerve trunks showed a major increase in endoneurial connective tissue. Despite this fact, regeneration of nerve with transfascicular infarct was far from complete even 16 months after injury as manifested by a striking increase in the small myelinated fibers (MF) number and decrease in large MF number. Restoration of infarcted nerves was less complete than that previously reported after a nerve crush. Changes in the necrotic nerve segment and difficulty in making target contact with muscle and other tissues damaged by ischemia may be limiting factors in the regeneration of infarcted nerves.
我们对猫后肢神经急性缺血性损伤后再生的进展进行了形态学研究。受损的神经干均未显示神经内膜结缔组织有明显增加。尽管如此，即使在损伤后16个月，伴有束内梗死的神经再生仍远未完成，表现为小髓鞘纤维（MF）数量显著增加，大MF数量减少。梗死神经的恢复不如先前报道的神经挤压伤后完全。坏死神经段的变化以及与因缺血而受损的肌肉和其他组织建立靶接触的困难可能是梗死神经再生的限制因素。
