Levantilides A 和 B，来源于一株分离自地中海深海沉积物的 Micromonospora 菌株的 20 元大环内酯。
Levantilides A and B, 20-membered macrolides from a Micromonospora strain isolated from the Mediterranean deep sea sediment.
机构信息
Kieler Wirkstoff-Zentrum at IFM-GEOMAR (Leibniz Institute of Marine Sciences), AmKiel-Kanal 44, 24106 Kiel, Germany.
出版信息
Mar Drugs. 2011 Jan 14;9(1):98-108. doi: 10.3390/md9010098.
Two new 20-membered macrolides, levantilide A and B, were isolated from the Micromonospora strain M71-A77. Strain M71-A77 was recovered from an Eastern Mediterranean deep-sea sediment sample and revealed to produce the levantilides under in situ salinity of 38.6 ‰. The chemical structures of the levantilides were elucidated on the basis of different one- and two- dimensional NMR experiments. Levantilide A exhibits a moderate antiproliferative activity against several tumor cell lines.
两种新的 20 元大环内酯类化合物，levantilide A 和 B，从 Micromonospora 菌株 M71-A77 中分离出来。M71-A77 菌株从东地中海深海沉积物样本中回收，并在原位盐度为 38.6 ‰的条件下产生 levantilides。基于不同的一维和二维 NMR 实验，阐明了 levantilides 的化学结构。Levantilide A 对几种肿瘤细胞系表现出中等的抗增殖活性。
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