Simons C J P, Jacobs N, Derom C, Thiery E, Jolles J, van Os J, Krabbendam L
Department of Psychiatry and Neuropsychology, Maastricht University, European Graduate School of Neuroscience, Maastricht, the Netherlands.
Acta Psychiatr Scand. 2009 Jul;120(1):45-52. doi: 10.1111/j.1600-0447.2008.01339.x. Epub 2009 Jan 7.
Previous studies have reported an association between depression and poor cognitive functioning. Unknown is to what degree such associations are merely state-related or reflect an enduring depression vulnerability. This study examined whether cognitive deficits predict current and/or follow-up (sub)clinical depressive symptoms in the general population.
A population-based sample of 569 female twins and 43 of their sisters completed a neuropsychological battery. Cross-sectional and prospective associations between depressive symptoms measured at the subclinical [Symptom Checklist-90 (SCL-90)] and clinical level (Structured Clinical Interview for DSM-IV disorders) and neuropsychological factors (episodic memory and information processing speed) were examined.
Structured Clinical Interview for DSM-IV disorders baseline depressive symptoms were significantly associated with information processing speed but not with episodic memory. Episodic memory was significantly associated with follow-up SCL-90 depressive symptoms.
Being depressed is accompanied by slower information processing. Poor memory functioning may be a predictor for the onset of subclinical depressive symptoms.
先前的研究报告了抑郁症与认知功能低下之间的关联。尚不清楚这种关联在多大程度上仅仅与当前状态相关，还是反映了一种持久的抑郁易感性。本研究调查了认知缺陷是否能预测普通人群当前和/或随访时的（亚）临床抑郁症状。
以社区为基础，对569名女性双胞胎及其43名姐妹进行抽样，她们完成了一套神经心理学测试。研究了在亚临床水平[症状自评量表90（SCL-90）]和临床水平（DSM-IV障碍的结构化临床访谈）测量的抑郁症状与神经心理学因素（情景记忆和信息处理速度）之间的横断面和前瞻性关联。
DSM-IV障碍的结构化临床访谈中，基线抑郁症状与信息处理速度显著相关，但与情景记忆无关。情景记忆与随访时的SCL-90抑郁症状显著相关。
抑郁伴随着较慢的信息处理速度。记忆功能不佳可能是亚临床抑郁症状发作的一个预测因素。
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