Department of Psychology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Peking University Sixth Hospital, Peking University Institute of Mental Health, No. 51 Huayuanbei Road, Beijing, 100191, China.
BMC Psychiatry. 2021 Apr 19;21(1):198. doi: 10.1186/s12888-021-03194-2.
Sleep disturbance and executive function impairment are common in patients with major depressive disorder (MDD), though the relationship between the two remains unclear. We investigated this association in first-episode, treatment-naïve patients with MDD.
We analyzed data from 242 patients with MDD. We divided the patients into 2 groups based on sleep disturbance severity and compared the executive function odds ratios between the groups.
A total of 121 pairs of patients were matched (age 39.4 ± 10.1, 70.2% female). After propensity score matching, the odds ratios for cognitive impairment in patients with MDD and severe sleep disturbance were 1.922 (1.068-3.459, P = 0.029, q = 0.044) in executive functioning; 2.023 (1.211-3.379, P = 0.007, q = 0.021) in executive shifting.
Sleep disturbance is associated with executive functioning impairment in first-episode, treatment-naïve patients with MDD. Severe sleep disturbance can be a marker and aid in recognizing executive function impairment in patients with first-episode treatment-naïve MDD. Severe sleep disturbance can be a potential modifiable factor to improve executive function in MDD, as well as an effective measurement to improve cognition for sleep symptom management that should be enforced at initial treatment of first-episode MDD. Further study is required to confirm our results.
ClinicalTrials.gov: NCT02023567 ; registration date: December 2013.
睡眠障碍和执行功能障碍在重度抑郁症（MDD）患者中很常见，但两者之间的关系尚不清楚。我们研究了首发、未经治疗的 MDD 患者中两者之间的关系。
我们分析了 242 例 MDD 患者的数据。我们根据睡眠障碍严重程度将患者分为 2 组，并比较了两组之间的执行功能比值比。
共匹配了 121 对患者（年龄 39.4±10.1，70.2%为女性）。在进行倾向评分匹配后，MDD 伴严重睡眠障碍患者认知障碍的比值比为 1.922（1.068-3.459，P=0.029，q=0.044），执行功能障碍为 2.023（1.211-3.379，P=0.007，q=0.021），执行转换。
首发、未经治疗的 MDD 患者的睡眠障碍与执行功能障碍有关。严重的睡眠障碍可以作为首发、未经治疗的 MDD 患者识别执行功能障碍的标志物和辅助手段。严重的睡眠障碍可能是改善 MDD 执行功能的潜在可调节因素，也是改善睡眠症状管理认知的有效衡量标准，应在初始治疗首发 MDD 时加以强化。需要进一步的研究来证实我们的结果。
ClinicalTrials.gov：NCT02023567；注册日期：2013 年 12 月。
