Jones Emily, Isom Scott, Kemper Kathi J, McLean Thomas W
Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
J Soc Integr Oncol. 2008 Fall;6(4):141-5.
The objective of this study was to determine the feasibility and effectiveness of acupressure therapy in preventing chemotherapy-associated nausea in children. A prospective, randomized, crossover trial was conducted among pediatric oncology patients at Brenner Children's Hospital (Winston-Salem, NC). Patients were randomized to one of two treatment sequences involving acupressure wrist bands and placebo bands, separated by a standard care treatment with no bands. All patients received standard antiemetic therapy for each treatment. Expectations and outcomes of nausea and vomiting were assessed by questionnaires. Of 21 patients approached, 21 were enrolled and 18 completed all three study treatments. Patients' ages ranged from 5 to 19 years, 14 of 18 were Caucasian, and 9 were male. In general, patients expressed moderate expectations that acupressure would prevent nausea and vomiting. Following the session with an acupressure band, a third of all patients reported better than expected nausea prevention. There was no significant difference in nausea or vomiting between the three groups; there were no significant side effects from acupressure or placebo bands. Pediatric oncology patients have moderate expectations about the effectiveness of acupressure in preventing nausea and vomiting. Acupressure is feasible and well tolerated but was not more effective than placebo in this sample of patients who were also treated with standard antiemetic therapies.
本研究的目的是确定指压疗法预防儿童化疗相关性恶心的可行性和有效性。在布伦纳儿童医院（北卡罗来纳州温斯顿 - 塞勒姆）的儿科肿瘤患者中进行了一项前瞻性、随机、交叉试验。患者被随机分配到两个治疗序列之一，这两个序列涉及指压腕带和安慰剂腕带，中间间隔一个不使用腕带的标准护理治疗。所有患者在每种治疗中均接受标准的止吐治疗。通过问卷调查评估恶心和呕吐的预期及结果。在21名被邀请的患者中，21名被纳入研究，18名完成了所有三种研究治疗。患者年龄在5至19岁之间，18名患者中有14名是白种人，9名是男性。总体而言，患者对指压预防恶心和呕吐抱有适度期望。在使用指压腕带治疗后，三分之一的患者报告恶心预防效果优于预期。三组之间在恶心或呕吐方面没有显著差异；指压腕带或安慰剂腕带均未产生显著副作用。儿科肿瘤患者对指压预防恶心和呕吐的有效性抱有适度期望。指压是可行的且耐受性良好，但在同时接受标准止吐治疗的该组患者中，其效果并不比安慰剂更显著。
