Gottschling S, Reindl T K, Meyer S, Berrang J, Henze G, Graeber S, Ong M F, Graf N
Department of Pediatric Hematology and Oncology, Saarland University, Homburg, Germany.
Klin Padiatr. 2008 Nov-Dec;220(6):365-70. doi: 10.1055/s-0028-1086039. Epub 2008 Oct 23.
We investigated whether acupuncture as a supportive antiemetic approach reduces the need for antiemetic rescue medication during highly emetogenic chemotherapy in pediatric oncology. We report on a multicenter crossover study at 5 tertiary hospitals in Germany.
Twenty-three children (13.6 y,+/- 2.9) receiving highly emetogenic chemotherapy for treatment of solid malignant tumors were included. Patients were randomly allocated to receive acupuncture treatment during either the second or third identical chemotherapy course together with standard antiemetic medication. The main outcome measure was the amount of additional antiemetic medication during chemotherapy. Secondary outcome measure was the number of episodes of vomiting per course.
Fourty-six chemotherapy courses with or without acupuncture were compared. The need for rescue antiemetic medication was significantly lower in acupuncture courses compared to control courses (p=0.001) Episodes of vomiting per course were also significantly lower in courses with acupuncture (p=0.01). Except for pain from needling (4/23) no side effects occurred. Patients acceptance of acupuncture was high.
Acupuncture as applied here seems to be effective in preventing nausea and vomiting in pediatric cancer patients.
我们研究了针刺作为一种辅助性止吐方法，是否能减少儿童肿瘤患者在接受高致吐性化疗期间对抢救性止吐药物的需求。我们报告了在德国5家三级医院进行的一项多中心交叉研究。
纳入23名（13.6岁，±2.9岁）因实体恶性肿瘤接受高致吐性化疗的儿童。患者被随机分配在第二次或第三次相同化疗疗程中接受针刺治疗，并同时使用标准止吐药物。主要观察指标是化疗期间额外止吐药物的用量。次要观察指标是每个疗程的呕吐发作次数。
比较了46个有或没有针刺治疗的化疗疗程。与对照疗程相比，针刺疗程中对抢救性止吐药物的需求显著降低（p = 0.001）。针刺疗程中每个疗程的呕吐发作次数也显著减少（p = 0.01）。除了针刺疼痛（4/23）外，未出现其他副作用。患者对针刺的接受度很高。
此处应用的针刺似乎对预防儿童癌症患者的恶心和呕吐有效。
