用卡诺瓦处理的活化人巨噬细胞刺激的淋巴细胞增殖
Lymphocyte proliferation stimulated by activated human macrophages treated with Canova.
作者信息
Burbano Rommel Rodriguez, Leal Mariana Ferreira, da Costa Joana Borges, Bahia Marcelo de Olivieira, de Lima Patricia Danielle Lima, Khayat André Salim, Seligman Igor Chamon, de Assumpção Paulo Pimentel, Buchi Dorly de Freitas, Smith Marilia de Arruda Cardoso
机构信息
Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brazil.
出版信息
Homeopathy. 2009 Jan;98(1):45-8. doi: 10.1016/j.homp.2008.11.011.
INTRODUCTION
Canova (CA) is a homeopathic medication with immunomodulatory properties, recommended for patients with a depressed immune system. CA has been reported to increase in leukocyte numbers, cellular differentiation and reduction in tumor size.
AIM AND METHOD
Since CA may stimulate lymphocyte differentiation, proliferation, and/or survival, the aim of the present study was to compare the mitotic index (MI) of phytohemagglutinin-stimulated human lymphocytes cultured in a medium supplemented with human macrophages activated by CA, with lymphocytes cultured in a medium without CA-treated macrophages.
RESULTS
In this study, the MI of lymphocyte cultured received the medium containing CA-stimulated macrophages showed a higher proliferation index (p<0.01) than the lymphocytes cultured in a medium without CA-treated macrophages. Our results suggest that CA treatment, in addition to activating macrophages, indirectly induces lymphocyte proliferation and has potential as a new adjuvant therapeutic approach.
引言
卡诺瓦（CA）是一种具有免疫调节特性的顺势疗法药物，推荐用于免疫系统低下的患者。据报道，CA可增加白细胞数量、促进细胞分化并减小肿瘤大小。
目的与方法
由于CA可能刺激淋巴细胞分化、增殖和/或存活，本研究的目的是比较在添加了经CA激活的人巨噬细胞的培养基中培养的植物血凝素刺激的人淋巴细胞的有丝分裂指数（MI），与在没有经CA处理的巨噬细胞的培养基中培养的淋巴细胞的有丝分裂指数。
结果
在本研究中，接受含有CA刺激的巨噬细胞的培养基培养的淋巴细胞的MI显示出比在没有经CA处理的巨噬细胞的培养基中培养的淋巴细胞更高的增殖指数（p<0.01）。我们的结果表明，CA治疗除了激活巨噬细胞外，还间接诱导淋巴细胞增殖，具有作为一种新的辅助治疗方法的潜力。
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