Wang B, Kennan W S, Yasukawa-Barnes J, Lindstrom M J, Gould M N
Environmental Toxicology Center, University of Wisconsin-Madison 53792.
Cancer Res. 1991 Oct 15;51(20):5649-54.
Varying results have been reported on the role of neu oncogene in mammary carcinogenesis. In order to further address this issue, the activated neu oncogene was introduced into mammary epithelial cells in situ of both mammary carcinoma-susceptible Wistar Furth and resistant Copenhagen rats by infusing replication-defective recombinant retroviruses carrying the neu oncogene into the mammary gland lumen. At the highest virus titer tested, very high numbers of mammary carcinomas developed within 2 weeks in all exposed glands in both rat strains. When the virus titer was reduced, however, individual tumors occurred with varying latencies. In addition, not all of the neu-infected mammary cells progressed to form mammary carcinomas. These results suggest that while neu is a potent mammary transforming gene, either other events in addition to neu expression may be required for full malignant transformation or not all mammary ductal epithelial cells are able to be neoplastically transformed.
关于neu癌基因在乳腺癌发生过程中的作用，已有不同的研究结果报道。为了进一步探讨这个问题，通过将携带neu癌基因的复制缺陷型重组逆转录病毒注入乳腺管腔，将激活的neu癌基因原位导入乳腺癌易感的Wistar Furth大鼠和抗性的哥本哈根大鼠的乳腺上皮细胞中。在测试的最高病毒滴度下，两种大鼠品系中所有暴露的腺体在2周内都出现了大量的乳腺癌。然而，当病毒滴度降低时，个别肿瘤出现的潜伏期各不相同。此外，并非所有被neu感染的乳腺细胞都会发展成乳腺癌。这些结果表明，虽然neu是一种强大的乳腺转化基因，但可能除了neu表达外，还需要其他事件才能实现完全的恶性转化，或者并非所有乳腺导管上皮细胞都能够发生肿瘤转化。
