Gintsburg A L, Zigangirova N A, Zorina V V
Vestn Ross Akad Med Nauk. 2008(10):34-9.
The current rise in the prevalence of chronic infectious diseases is in the first place attributable to the lack of efficacious antibacterial preparations to suppress pathogenic processes. The ability of pathogenic bacteria to long survive in tissue cells is due to the disturbance of protective reactions in the affected macroorganisms. Hence, the importance of investigations into the mechanisms underlying the bacterial action for the search of novel microbial targets and the development of a new generation of efficacious antibiotic drugs. Pathogenic microorganisms realize their virulent properties via type III secretion system that appears to be a most promising physiological target for drug therapy playing important role in the interaction of the pathogen with the host cells, its specific inhibition to reduce virulence of the pathogen and its elimination by the immune system.
当前慢性传染病患病率的上升首先归因于缺乏有效的抗菌制剂来抑制致病过程。病原菌在组织细胞中长期存活的能力是由于受影响的宏观生物体中保护反应的紊乱。因此，研究细菌作用的潜在机制对于寻找新的微生物靶点和开发新一代有效的抗生素药物至关重要。致病微生物通过III型分泌系统实现其毒力特性，该系统似乎是药物治疗最有前景的生理靶点，在病原体与宿主细胞的相互作用中起重要作用，对其进行特异性抑制可降低病原体的毒力并使其被免疫系统清除。
