Kariagina A S, Zigangirova N A, Grishin A V, Davydova D Iu, Krivozubov M S, Kirsanov D D, Zaiakin E S
Vestn Ross Akad Med Nauk. 2011(10):22-8.
Persistence is a form of interaction of pathogenic bacteria with a host aimed to promote their long-term survivalby means of inactivation of the host's protective systems via modulation of intracellular signal pathways. Persistent forms of a pathogen are refractory to traditional antibiotic therapy and cause chronic infectious diseases. Directed search for protein targets and new antibacterial drugs using computer simulation and experimental testing for the development of innovative preparations to treat chronic bacterial infections appears to have good prospects as a method for the management of persistent infections. A stepwise strategy for realization of such approach is exemplified by the search of preparations against chlamydial infection.
持续性是病原菌与宿主相互作用的一种形式，旨在通过调节细胞内信号通路使宿主保护系统失活，从而促进病原菌的长期存活。病原菌的持续性形式对传统抗生素治疗具有抗性，并会引发慢性传染病。利用计算机模拟和实验测试来直接寻找蛋白质靶点和新型抗菌药物，以开发治疗慢性细菌感染的创新制剂，作为一种管理持续性感染的方法似乎具有良好的前景。针对衣原体感染寻找制剂就是实现这种方法的逐步策略的一个例子。
