N-甲基-D-天冬氨酸（NMDA）受体激动剂D-环丝氨酸可促进人类的恐惧记忆巩固。
The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans.
作者信息
Kalisch Raffael, Holt Beatrice, Petrovic Predrag, De Martino Benedetto, Klöppel Stefan, Büchel Christian, Dolan Raymond J
机构信息
Functional Imaging Laboratory, Wellcome Department of Imaging Neuroscience, University College London, London, UK.
出版信息
Cereb Cortex. 2009 Jan;19(1):187-96. doi: 10.1093/cercor/bhn076. Epub 2008 May 13.
Abstract
Animal research suggests that the consolidation of fear and extinction memories depends on N-methyl D-aspartate (NMDA)-type glutamate receptors. Using a fear conditioning and extinction paradigm in healthy normal volunteers, we show that postlearning administration of the NMDA partial agonist D-cycloserine (DCS) facilitates fear memory consolidation, evidenced behaviorally by enhanced skin conductance responses, relative to placebo, for presentations of a conditioned stimulus (CS) at a memory test performed 72 h later. DCS also enhanced CS-evoked neural responses in a posterior hippocampus/collateral sulcus region and in the medial prefrontal cortex at test. Our data suggest a role for NMDA receptors in regulating fear memory consolidation in humans.
摘要
动物研究表明，恐惧记忆和消退记忆的巩固依赖于N-甲基-D-天冬氨酸（NMDA）型谷氨酸受体。在健康正常志愿者中采用恐惧条件反射和消退范式，我们发现，与安慰剂相比，在学习后给予NMDA部分激动剂D-环丝氨酸（DCS）可促进恐惧记忆巩固，在72小时后进行的记忆测试中，条件刺激（CS）呈现时增强的皮肤电导反应即为行为学证据。在测试时，DCS还增强了后海马/侧副沟区域以及内侧前额叶皮质中CS诱发的神经反应。我们的数据表明NMDA受体在调节人类恐惧记忆巩固中发挥作用。
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