Peng Hui, Zhang Lijuan, Soeller Christian, Travas-Sejdic Jadranka
Polymer Electronic Research Centre, The University of Auckland, Private Bag, Auckland, New Zealand.
Biomaterials. 2009 Apr;30(11):2132-48. doi: 10.1016/j.biomaterials.2008.12.065. Epub 2009 Jan 14.
Conducting polymers (CPs) are a class of polymeric materials that have attracted considerable interest because of their unique electronic, chemical and biochemical properties, making them suitable for numerous applications such as energy storage, memory devices, chemical sensors, and in electrocatalysis. Conducting polymer-based electrochemical DNA sensors have shown applicability in a number of areas related to human health such as diagnosis of infectious diseases, genetic mutations, drug discovery, forensics and food technology due to their simplicity and high sensitivity. This review paper summarizes the advances in electrochemical DNA sensing based on conducting polymers as active substrates. The various conducting polymers used for DNA detection, along with different DNA immobilization and detection methodologies are presented. Current trends in this field and newly developed applications due to advances in nanotechnology are also discussed.
导电聚合物(CPs)是一类聚合材料,因其独特的电子、化学和生化特性而备受关注,这使得它们适用于众多应用,如能量存储、记忆器件、化学传感器以及电催化领域。基于导电聚合物的电化学DNA传感器由于其操作简单和高灵敏度,已在与人类健康相关的多个领域显示出适用性,如传染病诊断、基因突变检测、药物发现、法医学和食品技术等。这篇综述文章总结了以导电聚合物作为活性底物的电化学DNA传感技术的进展。文中介绍了用于DNA检测的各种导电聚合物,以及不同的DNA固定和检测方法。还讨论了该领域的当前趋势以及由于纳米技术进步而新开发的应用。