Max Planck Tandem Group in Nanobioengineering, Institute of Chemistry, Faculty of Natural and Exact Sciences, University of Antioquia, Complejo Ruta N, Calle 67 N° 52-20, Medellin 050010, Colombia.
Molecules. 2022 Jun 15;27(12):3841. doi: 10.3390/molecules27123841.
Nanoengineering biosensors have become more precise and sophisticated, raising the demand for highly sensitive architectures to monitor target analytes at extremely low concentrations often required, for example, for biomedical applications. We review recent advances in functional nanomaterials, mainly based on novel organic-inorganic hybrids with enhanced electro-physicochemical properties toward fulfilling this need. In this context, this review classifies some recently engineered organic-inorganic metallic-, silicon-, carbonaceous-, and polymeric-nanomaterials and describes their structural properties and features when incorporated into biosensing systems. It further shows the latest advances in ultrasensitive electrochemical biosensors engineered from such innovative nanomaterials highlighting their advantages concerning the concomitant constituents acting alone, fulfilling the gap from other reviews in the literature. Finally, it mentioned the limitations and opportunities of hybrid nanomaterials from the point of view of current nanotechnology and future considerations for advancing their use in enhanced electrochemical platforms.
纳米工程生物传感器变得更加精确和复杂，提高了对高灵敏度架构的需求，以监测通常需要的极低浓度的目标分析物，例如，用于生物医学应用。我们回顾了功能纳米材料的最新进展，主要基于具有增强的电物理化学性质的新型有机-无机杂化材料，以满足这一需求。在这种情况下，本综述将一些最近设计的有机-无机金属、硅、碳质和聚合物纳米材料进行了分类，并描述了它们在被纳入生物传感系统时的结构特性和特点。它进一步展示了最新的基于此类创新纳米材料的超灵敏电化学生物传感器的进展，突出了它们相对于单独作用的共存成分的优势，弥补了文献中其他综述的空白。最后，从当前纳米技术的角度提到了混合纳米材料的局限性和机遇，并对未来在增强电化学平台中使用它们进行了考虑。
