Collins Ben, Blau Justin
Biology Department, New York University, 100 Washington Square East, New York, New York 10003, USA.
Neuron. 2006 May 4;50(3):348-50. doi: 10.1016/j.neuron.2006.04.022.
The accepted dogma in circadian biology is that the transcription factor CLOCK lies at the heart of the molecular clock that drives behavioral and molecular rhythms. In this issue of Neuron, the generation of CLOCK-deficient mice with only subtle clock defects by DeBruyne et al. shakes up this view of the mammalian clock.
昼夜节律生物学中公认的教条是，转录因子CLOCK处于驱动行为和分子节律的分子时钟的核心位置。在本期《神经元》杂志中，德布鲁因等人培育出的仅存在细微时钟缺陷的CLOCK基因敲除小鼠，动摇了人们对哺乳动物生物钟的这一观点。
