2004年至2006年期间，耐受性良好的化学预防措施成功地使瑞典士兵在利比里亚免受恶性疟原虫疟疾的侵袭。
Well-tolerated chemoprophylaxis uniformly prevented Swedish soldiers from Plasmodium falciparum malaria in Liberia, 2004-2006.
作者信息
Andersson Håkan, Askling Helena H, Falck Björn, Rombo Lars
机构信息
Swedish Armed Forces, Livgardet, Kungsängen, Stockholm, Sweden.
出版信息
Mil Med. 2008 Dec;173(12):1194-8. doi: 10.7205/milmed.173.12.1194.
BACKGROUND
Between 2004 and 2006, 1,170 Swedish soldiers were deployed to Liberia. They were prescribed mefloquine or atovaquone/proguanil as malaria chemoprophylaxis. Our study aims were to estimate the chemoprophylaxis effectiveness and adverse events.
METHODS
Cases of malaria were routinely reported during and after the mission. After return to Sweden, the soldiers filled in a questionnaire concerning type of accommodation, use of prophylaxis, and adverse events.
RESULTS
No cases of Plasmodium falciparum malaria were recorded during a total of approximately 7,000 person-months. Adverse events (AE) were reported by 57% in the mefloquine group and 34% in the atovaquone/proguanil group. In the mefloquine group, the soldiers reported more neuropsychological AE.
CONCLUSIONS
Both drugs were safe and 100% effective as long-term prophylaxis for prevention of P. falciparum malaria. Atovaquone/ proguanil was better tolerated with respect to self-reported AE.
背景
2004年至2006年期间，1170名瑞典士兵被部署到利比里亚。他们被开了甲氟喹或阿托伐醌/氯胍作为疟疾化学预防药物。我们的研究目的是评估化学预防的有效性和不良事件。
方法
在任务期间及之后定期报告疟疾病例。回到瑞典后，士兵们填写了一份关于住宿类型、预防药物使用情况和不良事件的问卷。
结果
在总共约7000人月的时间里，未记录到恶性疟原虫疟疾病例。甲氟喹组报告不良事件的比例为57%，阿托伐醌/氯胍组为34%。在甲氟喹组中，士兵们报告了更多的神经心理不良事件。
结论
两种药物作为预防恶性疟原虫疟疾的长期预防药物都是安全且100%有效的。就自我报告的不良事件而言，阿托伐醌/氯胍的耐受性更好。
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