Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA.
J Perinatol. 2010 Oct;30 Suppl:S73-81. doi: 10.1038/jp.2010.93.
The implementation of amplitude-integrated electroencephalography (aEEG) has enhanced the neurological monitoring of critically ill infants. Limited channel leads are applied to the patient and data are displayed in a semilogarithmic, time-compressed scale. Several classifications are currently in use to describe patient tracings, incorporating voltage criteria, pattern recognition, cyclicity, and the presence or absence of seizures. In term neonates, aEEG has been used to determine the prognosis and treatment for those affected by hypoxic-ischemic encephalopathy, seizures, meningitis and even congenital heart disease. Its application as inclusion criteria for therapeutic hypothermia remains controversial. In preterm infants, normative values and patterns corresponding to gestational age are being established. As these standards emerge, the predictive value of aEEG increases, especially in the setting of preterm brain injury and intraventricular hemorrhage. The sensitivity and specificity of aEEG are enhanced by the display of a simultaneous raw EEG, which aids interpretation. Caution must be taken when using and interpreting this tool in conjunction with certain medications and in the setting of less experienced staff. Continuing efforts at developing software that can aid seizure detection and background classification will enhance the bedside utility of this tool.
振幅整合脑电图（aEEG）的实施增强了对危重症婴儿的神经监测。将有限数量的导联应用于患者，数据以半对数、时间压缩的比例显示。目前有几种分类方法用于描述患者的描记图，包括电压标准、模式识别、周期性和有无癫痫发作。在足月新生儿中，aEEG 已用于确定缺氧缺血性脑病、癫痫发作、脑膜炎甚至先天性心脏病患儿的预后和治疗。其作为治疗性低温治疗的纳入标准仍存在争议。在早产儿中，正在建立与胎龄相对应的正常值和模式。随着这些标准的出现，aEEG 的预测价值增加，特别是在早产儿脑损伤和脑室出血的情况下。通过显示同时的原始脑电图，aEEG 的敏感性和特异性得到增强，这有助于解释。在使用和解释该工具时，必须谨慎对待某些药物的使用和经验不足的工作人员的情况。不断努力开发能够辅助癫痫发作检测和背景分类的软件将增强该工具的床边实用性。
