刺蒺藜中的甾体皂苷。

Steroidal saponins from Tribulus terrestris.

作者信息

Su Lan, Chen Gang, Feng Sheng-Guang, Wang Wei, Li Zhi-Feng, Chen Huan, Liu Ying-Xue, Pei Yue-Hu

机构信息

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenyang 110016, PR China.

出版信息

Steroids. 2009 Apr-May;74(4-5):399-403. doi: 10.1016/j.steroids.2008.12.008. Epub 2008 Dec 30.

DOI:10.1016/j.steroids.2008.12.008

PMID:19152803

Abstract

Five new steroidal saponins were isolated from the fruits of Tribulus terrestris. Their structures were fully established by spectroscopic and chemical analysis as (23S,25S)-5alpha-spirostane-24-one-3beta,23-diol-3-O-{alpha-l-rhamnopyranosyl-(1-->2)-O-[beta-d-glucopyranosyl-(1-->4)]-beta-d-galactopyranoside} (1), (24S,25S)-5alpha-spirostane-3beta,24-diol-3-O-{alpha-l-rhamnopyranosyl-(1-->2)-O-[beta-d-glucopyranosyl-(1-->4)]-beta-d-galactopyranoside} (2), 26-O-beta-d-glucopyranosyl-(25R)-5alpha-furostan-2alpha,3beta,22alpha,26-tetraol-3-O-{beta-d-glucopyranosyl-(1-->2)-O-beta-d-glucopyranosyl-(1-->4)-beta-d-galactopyranoside} (3), 26-O-beta-d-glucopyranosyl-(25R)-5alpha-furostan-20(22)-en-2alpha,3beta,26-triol-3-O-{beta-d-glucopyranosyl-(1-->2)-O-beta-d-glucopyranosyl-(1-->4)-beta-d-galactopyranoside} (4), and 26-O-beta-d-glucopyranosyl-(25S)-5alpha-furostan-12-one-22-methoxy-3beta,26-diol-3-O-{alpha-l-rhamnopyranosyl-(1-->2)-O-[beta-d-glucopyranosyl-(1-->4)]-beta-d-galactopyranoside} (5). The isolated compounds were evaluated for cytostatic activity against HL-60 cells.

摘要

从刺蒺藜果实中分离出5种新的甾体皂苷。通过光谱和化学分析完全确定了它们的结构，分别为(23S,25S)-5α-螺旋甾烷-24-酮-3β,23-二醇-3-O-{α-L-鼠李糖基-(1→2)-O-[β-D-葡萄糖基-(1→4)]-β-D-半乳糖苷}(1)、(24S,25S)-5α-螺旋甾烷-3β,24-二醇-3-O-{α-L-鼠李糖基-(1→2)-O-[β-D-葡萄糖基-(1→4)]-β-D-半乳糖苷}(2)、26-O-β-D-葡萄糖基-(25R)-5α-呋甾烷-2α,3β,22α,26-四醇-3-O-{β-D-葡萄糖基-(1→2)-O-β-D-葡萄糖基-(1→4)-β-D-半乳糖苷}(3)、26-O-β-D-葡萄糖基-(25R)-5α-呋甾烷-20(22)-烯-2α,3β,26-三醇-3-O-{β-D-葡萄糖基-(1→2)-O-β-D-葡萄糖基-(1→4)-β-D-半乳糖苷}(4)和26-O-β-D-葡萄糖基-(25S)-5α-呋甾烷-12-酮-22-甲氧基-3β,26-二醇-3-O-{α-L-鼠李糖基-(1→2)-O-[β-D-葡萄糖基-(1→4)]-β-D-半乳糖苷}(5)。对分离得到的化合物进行了抗HL-60细胞的细胞生长抑制活性评价。