Stopfkuchen H, Racké K, Schwörer H, Queisser-Luft A, Vogel K
Universitätskinderklinik, Johannes Gutenberg-Universität, Mainz, Federal Republic of Germany.
Eur J Pediatr. 1991 May;150(7):503-6. doi: 10.1007/BF01958433.
Newborn infants (21 preterm and 13 term) received dopamine infusions at a low (2.5-3.4 micrograms/kg per min) and/or high (5-10 micrograms/kg per min) infusion rate and changes in plasma catecholamines were monitored. The mean baseline values for dopamine, noradrenaline and adrenaline were between 240 and 560, 125 and 144 and 62 and 82 pg/ml, respectively. During low-rate infusion of dopamine, there was a significant increase in plasma dopamine (20-100 fold), noradrenaline (three- to five-fold) and adrenaline (threefold). Administration of dopamine at the high rate resulted in an even larger increase in the plasma catecholamines (dopamine, 100-300 fold; noradrenaline, seven- to eightfold; adrenaline, four- to sixfold). In a double-log plot, there was a highly significant correlation between the plasma concentrations of dopamine and noradrenaline (r = 0.77; P less than 0.001). In conclusion, infusion of dopamine in term and preterm newborn infants is accompanied by an enhanced sympatho-adrenal tone which may contribute to the cardiovascular effects of dopamine in these patients.
对新生儿（21例早产儿和13例足月儿）以低（2.5 - 3.4微克/千克每分钟）和/或高（5 - 10微克/千克每分钟）输注速率输注多巴胺，并监测血浆儿茶酚胺的变化。多巴胺、去甲肾上腺素和肾上腺素的平均基线值分别在240至560、125至144和62至82皮克/毫升之间。在低速率输注多巴胺期间，血浆多巴胺（增加20 - 100倍）、去甲肾上腺素（增加三至五倍）和肾上腺素（增加三倍）显著增加。以高速率给予多巴胺导致血浆儿茶酚胺进一步大幅增加（多巴胺，增加100 - 300倍；去甲肾上腺素，增加七至八倍；肾上腺素，增加四至六倍）。在双对数图中，多巴胺和去甲肾上腺素的血浆浓度之间存在高度显著的相关性（r = 0.77；P < 0.001）。总之，对足月儿和早产儿输注多巴胺伴随着交感 - 肾上腺张力增强，这可能是多巴胺对这些患者产生心血管效应的原因。
