The Heart Centre, Division of Lung Transplantation, Rigshospitalet, University of Copenhagen, Denmark.
Respir Med. 2009 Jun;103(6):913-8. doi: 10.1016/j.rmed.2008.12.007. Epub 2009 Jan 19.
To describe health-related quality of life (hrQOL) in adult subjects who had sarcoidosis in childhood.
Forty-six children (24 boys), all ethnic Danes <or=15 years of age with sarcoidosis were recorded in Denmark in 1979-1994. Three patients were deceased prior to this study. At follow-up, the 43 surviving adult subjects were invited to complete the short-form health survey questionnaire SF-36, being completed by 34 subjects (14 men). SF-36 scores were compared with the scores in the Danish reference population.
At follow-up, 30/34 patients had recovered from sarcoidosis and 4/34 patients had persistent chronic active disease with impaired lung function. SF-36 scores in all domains were similar to scores in the reference population; the four patients with chronic active disease had lower scores in three domains. In the entire series, physical component summary (PCS) score and mental component summary (MCS) score was similar to the reference population.
Childhood sarcoidosis has a favourable prognosis concerning health status in adulthood. The majority of adult subjects had a health status that was indistinguishable from a healthy reference population.
描述儿童期罹患结节病的成年患者的健康相关生活质量（hrQOL）。
1979 年至 1994 年间，丹麦共记录了 46 名（24 名男性）<15 岁的丹麦裔结节病患儿。在此项研究之前，有 3 名患者死亡。随访时，邀请 43 名幸存的成年患者完成简明健康调查问卷 SF-36，其中 34 名患者（14 名男性）完成了问卷。将 SF-36 评分与丹麦参考人群的评分进行比较。
随访时，30/34 例患者已从结节病中康复，4/34 例患者患有持续性慢性活动性疾病，伴有肺功能受损。所有领域的 SF-36 评分均与参考人群的评分相似；4 例患有慢性活动性疾病的患者在三个领域的评分较低。在整个系列中，生理成分综合评分（PCS）和心理成分综合评分（MCS）与参考人群相似。
儿童期结节病的成年患者的健康状况具有良好的预后。大多数成年患者的健康状况与健康参考人群无异。
