蛋白激酶激活环顺式自磷酸化：克服两难困境。

Protein kinase activation loop autophosphorylation in cis: overcoming a Catch-22 situation.

作者信息

Lochhead Pamela A

机构信息

The Laboratory of Molecular Signalling, The Babraham Research Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.

出版信息

Sci Signal. 2009 Jan 20;2(54):pe4. doi: 10.1126/scisignal.254pe4.

DOI:10.1126/scisignal.254pe4

PMID:19155529

Abstract

Autophosphorylation of the activation loop in cis is an underappreciated and poorly understood mode of activation of protein kinases. Here, I describe four examples of protein kinases that are activated in this way, concentrating on their biochemical properties and how their autophosphorylation in cis is achieved.

摘要

同一分子内激活环的自磷酸化是一种未得到充分重视且了解甚少的蛋白激酶激活模式。在此，我描述了以这种方式激活的四种蛋白激酶实例，重点介绍它们的生化特性以及它们如何实现同一分子内的自磷酸化。