Johnson T E, Nelson G A
Department of Psychology, University of Colorado, Boulder 80309.
Exp Gerontol. 1991;26(2-3):299-309. doi: 10.1016/0531-5565(91)90024-g.
The utility of the nematode Caenorhabditis elegans in studies spanning aspects of development, aging, and radiobiology is reviewed. These topics are interrelated via cellular and DNA repair processes especially in the context of oxidative stress and free-radical metabolism. The relevance of these research topics to problems in space biology is discussed and properties of the space environment are outlined. Exposure to the space-flight environment can induce rapid changes in living systems that are similar to changes occurring during aging; manipulation of these environmental parameters may represent an experimental strategy for studies of development and senscence. The current and future opportunities for such space-flight experimentation are presented.
综述了线虫秀丽隐杆线虫在发育、衰老和放射生物学等方面研究中的应用。这些主题通过细胞和DNA修复过程相互关联，尤其是在氧化应激和自由基代谢的背景下。讨论了这些研究主题与空间生物学问题的相关性，并概述了空间环境的特性。暴露于太空飞行环境可诱导生命系统发生快速变化，这些变化类似于衰老过程中发生的变化；操纵这些环境参数可能代表一种研究发育和衰老的实验策略。介绍了此类太空飞行实验的当前和未来机会。
