Turkkan Ebru, Uslan Ihsan, Acarturk Gursel, Topak Nevin, Kahraman Ahmet, Dilek Fatma Husniye, Akcan Yusuf, Karaman Ozcan, Colbay Mehmet, Yuksel Seref
Department of Internal Medicine, School of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
J Gastroenterol. 2009;44(1):66-70. doi: 10.1007/s00535-008-2271-9. Epub 2009 Jan 22.
Inflammation induces some structural and biochemical alterations and oxidative damage in gastric tissue. In this study, we aimed to investigate the relationship among the severity of symptoms, oxidative stress, and grading scales of Helicobacter pylori-induced gastric inflammation in functional dyspepsia.
Thirty-five patients with functional dyspepsia were enrolled in the study. The severity of dyspepsia within the last 6 months was evaluated by Glasgow Dyspepsia Severity Score. In biopsy specimens of gastric mucosa, severity of gastritis was estimated by the revised Sydney Classification System, and oxidative stress parameters were studied.
Although there was no statistically significant relationship between symptom scores and degree of chronic inflammation, a tendency for symptoms to be more severe has been observed in low levels of gastritis. Levels of sulfhydryl groups were lower in subjects with high levels of chronic inflammation, and Helicobacter pylori intensity (P < 0.001 and P = 0.02, respectively). Levels of malondialdehyde were higher in subjects with high levels of chronic inflammation (P = 0.04). There was a statistically significant but a weak positive correlation between symptom scores and sulfhydryl levels (P < 0.001, r = 0.323).
In conclusion, there may be an inverse relation between severity of symptoms and level of Helicobacter pylori induced gastric inflammation or oxidative stress in patients with functional dyspepsia.
炎症会导致胃组织出现一些结构和生化改变以及氧化损伤。在本研究中，我们旨在探讨功能性消化不良患者症状严重程度、氧化应激与幽门螺杆菌诱导的胃炎症分级之间的关系。
35例功能性消化不良患者纳入本研究。采用格拉斯哥消化不良严重程度评分评估过去6个月内消化不良的严重程度。在胃黏膜活检标本中，采用修订的悉尼分类系统评估胃炎严重程度，并研究氧化应激参数。
虽然症状评分与慢性炎症程度之间无统计学显著相关性，但在轻度胃炎患者中观察到症状有更严重的趋势。慢性炎症程度高的受试者中巯基水平较低，幽门螺杆菌强度也较低（分别为P < 0.001和P = 0.02）。慢性炎症程度高的受试者中丙二醛水平较高（P = 0.04）。症状评分与巯基水平之间存在统计学显著但较弱的正相关（P < 0.001，r = 0.323）。
总之，功能性消化不良患者症状严重程度与幽门螺杆菌诱导的胃炎症水平或氧化应激之间可能存在负相关。
