(, Hp) colonizes the stomachs of approximately 20%-80% of humans throughout the world. The Word Healthy Organization (WHO) classified as a group 1 carcinogenic factor in 1994. Recently, an increasing number of studies has shown an association between infection and various extragastric diseases. Functional dyspepsia (FD) is considered a biopsychosocial disorder with multifactorial pathogenesis, and studies have shown that infection with CagA-positive strains could explain some of the symptoms of functional dyspepsia. Moreover, CagA-positive strains have been shown to affect the secretion of several hormones, including 5-HT, ghrelin, dopamine, and gastrin, and altered levels of these hormones might be the cause of the psychological disorders of functional dyspepsia patients. This review describes the mutual effects of and hormones in functional dyspepsia and provides new insight into the pathogenesis of functional dyspepsia.