Suppr超能文献

巴勒斯坦领土内的近亲结婚与生殖损耗

Consanguinity and reproductive wastage in the Palestinian Territories.

作者信息

Assaf Shireen, Khawaja Marwan, DeJong Jocelyn, Mahfoud Ziad, Yunis Khalid

机构信息

Department of Epidemiology and Population Health, American University of Beirut, Beirut, Lebanon.

出版信息

Paediatr Perinat Epidemiol. 2009 Mar;23(2):107-15. doi: 10.1111/j.1365-3016.2008.00988.x.

Abstract

Many studies have found that consanguinity poses a threat to child mortality and health and can also pose a threat to offspring survival before birth. However, there are conflicting findings with some studies having found no increased risk on offspring survival associated with consanguinity. Data from a population-based survey conducted in 2004 in the Palestinian Territories was used to assess the risk of consanguinity on offspring survival. The analysis was conducted on 4418 women aged 15-49 who were asked whether or not they had experienced a stillbirth or a spontaneous abortion. These two outcomes were combined together for the analysis of reproductive wastage. Multivariable negative binomial regression was conducted to calculate the incidence risk ratios (IRR) for each region in the Palestinian Territories separately. The strongest risk factors for reproductive wastage, after controlling for other variables, were found to be consanguinity, age and parity with age presenting the highest IRRs. Standard of living, locality type, education level, women's employment and past intrauterine device use were not found to be significant risk factors for reproductive wastage. In the West Bank only first cousin level of consanguinity was found to be significant and 'hamola' level (or from same family clan) lost its significance after adjusting for other variables. In the Gaza Strip both the first cousin and 'hamola' levels of consanguinity were significant and presented almost equal IRRs of 1.3. In conclusion, consanguinity was found to be a significant risk factor for reproductive wastage.

摘要

许多研究发现,近亲结婚对儿童死亡率和健康构成威胁,也可能对胎儿出生前的存活构成威胁。然而,也有相互矛盾的研究结果,一些研究发现近亲结婚与后代存活风险增加并无关联。2004年在巴勒斯坦地区进行的一项基于人群的调查数据被用于评估近亲结婚对后代存活的风险。对4418名年龄在15至49岁之间的女性进行了分析,询问她们是否经历过死产或自然流产。这两种情况被合并用于分析生殖损耗。分别对巴勒斯坦地区的每个区域进行多变量负二项回归,以计算发病风险比(IRR)。在控制其他变量后,发现生殖损耗的最强风险因素是近亲结婚、年龄和产次,其中年龄的发病风险比最高。生活水平、地区类型、教育程度、女性就业情况和过去使用宫内节育器的情况未被发现是生殖损耗的显著风险因素。在约旦河西岸,仅一级表亲的近亲结婚程度被发现具有显著性,而“hamola”级(或同一家族)在调整其他变量后失去了显著性。在加沙地带,一级表亲和“hamola”级的近亲结婚程度均具有显著性,且发病风险比几乎相等,为1.3。总之,近亲结婚被发现是生殖损耗的一个显著风险因素。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验