Akbayram S, Sari N, Akgün C, Doğan M, Tuncer O, Caksen H, Oner A F
Department of Pediatrics, Yüzüncü Yil University Faculty of Medicine, Van, Turkey.
Genet Couns. 2009;20(3):207-14.
The frequency of consanguineous marriage in Eastern Turkey:
The rate of consanguineous marriage (CM) varies depended on different factors such as race, characteristics of population, and religion and moral features in different countries. Gene frequency and genetic structure are changed by CMs. The aim of the present study is to assess the prevalence of CM and its effects on miscarriage, stillbirth, congenital malformation and ratio of newborn death.
This study was performed in Van region, Eastern Turkey, between September 2005 and April 2006. A total of 650 families from 24 districts chosen in accordance with the number of inhabitants were included in this study. First cousin marriages were accepted as a first degree CMs, sesquialter and second cousin marriages as second degree and marriages between distant relatives were accepted as a third degree CM. Monthly income of the families was classified in accordance with minimum wage determined by government.
Of all families, 224 (34.4%) had CM, and 168 (75%) had first-degree consanguinity. A lower CM rate was found in mothers who graduated from secondary school or upgrading (p < 0.01). However, no relationship was found between CM and fathers' education level. While a low CM rate was found in families who had two or less children (p < 0.01), high rate was observed in families who had five or more children. In addition, a high rate of miscarriage, stillbirth and mental-motor retardation was found in families with CM (p < 0.05). The rate of child mortality between the aged 0-2 years was found to be higher in families with CM (p < 0.01). The higher CM rate was observed in families who married due to pressure or insistence of their families than married voluntarily (p < 0.05).
Our study showed that CM rate was very high, 34.4%, in our region Eastern Turkey.
土耳其东部近亲结婚的频率
近亲结婚（CM）的发生率因种族、人口特征、宗教和不同国家的道德特征等不同因素而有所变化。近亲结婚会改变基因频率和遗传结构。本研究的目的是评估近亲结婚的患病率及其对流产、死产、先天性畸形和新生儿死亡比例的影响。
本研究于2005年9月至2006年4月在土耳其东部的凡城地区进行。根据居民数量从24个区选取了总共650个家庭纳入本研究。一级表亲结婚被视为一级近亲结婚，半表亲和二级表亲结婚被视为二级近亲结婚，远亲之间的结婚被视为三级近亲结婚。家庭月收入根据政府确定的最低工资进行分类。
在所有家庭中，224个（34.4%）有近亲结婚情况，其中168个（75%）为一级近亲结婚。中学毕业或学历更高的母亲近亲结婚率较低（p<0.01）。然而，未发现近亲结婚与父亲教育水平之间存在关联。孩子数量为两个或更少的家庭近亲结婚率较低（p<0.01），而孩子数量为五个或更多的家庭近亲结婚率较高。此外，有近亲结婚情况的家庭流产、死产和精神运动发育迟缓的发生率较高（p<0.05）。0至2岁儿童死亡率在有近亲结婚情况的家庭中更高（p<0.01）。因家庭压力或坚持而结婚的家庭近亲结婚率高于自愿结婚的家庭（p<0.05）。
我们的研究表明，在我们土耳其东部地区，近亲结婚率非常高，为34.4%。
