Ukkola Olavi, Pöykkö Seppo, Päivänsalo Markku, Kesäniemi Y Antero
Department of Internal Medicine, University of Oulu, Finland.
Ann Med. 2008;40(6):465-73. doi: 10.1080/07853890802084860.
High leptin and low ghrelin are associated with the metabolic syndrome (MS).
Ghrelin, leptin (RIA kits), and insulin-like growth factor I (IGF-I) (ELISA kit) concentrations of the population-based cohort of 1045 subjects and their interactions with metabolic parameters were analysed. Intima-media thickness (IMT) was measured with carotid ultrasound.
The interaction between leptin and ghrelin on the MS was significant (P = 0.011). An additive effect of high leptin and low ghrelin on metabolic disturbances was observed: low ghrelin concentration (adjusted for age and sex) (P < 0.001) was associated with the MS and type 2 diabetes in the highest but not in the lower leptin quartiles. In the highest leptin quartile, ghrelin concentrations decreased linearly when the number of International Diabetes Federation MS criteria met (P < 0.01) increased. Ghrelin-leptin relation was independently associated with carotid IMT (P < 0.005). The independent positive association (P < 0.01) between the plasma ghrelin quartile and the carotid IMT was evident in the lowest IGF-I quartile.
Low ghrelin is associated with MS and type 2 diabetes in the presence of insulin and leptin resistance. Ghrelin-leptin relation is associated with early atherosclerosis. The interaction between IGF-I and ghrelin modifies the association of ghrelin with early atherosclerosis.
高瘦素和低胃饥饿素与代谢综合征（MS）相关。
分析了基于人群的1045名受试者队列中胃饥饿素、瘦素（放射免疫分析试剂盒）和胰岛素样生长因子I（IGF-I）（酶联免疫吸附测定试剂盒）的浓度及其与代谢参数的相互作用。用颈动脉超声测量内膜中层厚度（IMT）。
瘦素和胃饥饿素对MS的相互作用显著（P = 0.011）。观察到高瘦素和低胃饥饿素对代谢紊乱有相加作用：低胃饥饿素浓度（根据年龄和性别调整）（P < 0.001）与MS和2型糖尿病相关，在瘦素四分位数最高组而非较低组中如此。在瘦素四分位数最高组中，当符合国际糖尿病联盟MS标准的数量增加时（P < 0.01），胃饥饿素浓度呈线性下降。胃饥饿素-瘦素关系与颈动脉IMT独立相关（P < 0.005）。在IGF-I四分位数最低组中，血浆胃饥饿素四分位数与颈动脉IMT之间的独立正相关（P < 0.01）明显。
在存在胰岛素和瘦素抵抗的情况下，低胃饥饿素与MS和2型糖尿病相关。胃饥饿素-瘦素关系与早期动脉粥样硬化相关。IGF-I和胃饥饿素之间的相互作用改变了胃饥饿素与早期动脉粥样硬化的关联。
