伊斯法罕队列研究中代谢综合征患者与非代谢综合征患者的颈动脉内膜中层厚度与某些炎症生物标志物、胃饥饿素和脂联素之间的关系
Relationship Between Carotid Intima-Media Thickness with some Inflammatory Biomarkers, Ghrelin and Adiponectin in Iranians with and without Metabolic Syndrome in Isfahan Cohort Study.
作者信息
Hajmohammadi Taiebeh, Sadeghi Masoumeh, Dashti Masoumeh, Hashemi Mohammad, Saadatnia Mohammad, Soghrati Mojgan, Talaei Mohammad, Sarrafzadegan Nizal
机构信息
Resident of Cardiology, Isfahan University of Medical Sciences.
出版信息
ARYA Atheroscler. 2010 Summer;6(2):56-61.
BACKGROUND
Recent studies have confirmed inflammatory factors and metabolic syndrome (MetS) as important cardiovascular disease (CVD) risk factors. Recently measurement of carotid intima-media thickness (IMT) has been used for evaluation of early atherosclerosis. This study was designed to assess the correlation between IMT with some inflammatory biomarkers, ghrelin and adiponectin in people with and without MetS in a cohort sample in Isfahan province.
METHODS
Among participants of Isfahan Cohort Study (ICS) by random sampling, 88 participants were selected and divided into case (with MetS) and control (without MetS) groups. A questionnaire including demographic data and CVD risk factors was completed for all of the participants. Physical examination and blood pressure, height, weight and waist circumference measurements were done for all subjects. Vascular echocardiography was done for evaluation of IMT of each carotid artery of both sides. Interlukin-6 (IL-6), interlukin-10 (IL-10), highly sensitive C-reactive protein (hs-CRP), ghrelin and adiponectin levels were measured using ELIZA method. Data were entered in SPSS(15) software and analyzed by t-test, chi square, Pearson correlation and linear regression analyze.
RESULTS
The mean waist circumference, BMI, systolic blood pressure, diastolic blood pressure, hs-CRP and IMT of left carotid artery were significantly higher in participants with Mets. There was significant correlation between left carotid IMT and IL-6 level in all patients (P = 0.03). After adjustment for age and sex, significant relationship in groups with MetS was only reported between the left IMT and IL-6 (P = 0.02). There was no relation between IMT and other inflammatory markers in subjects with and without MetS.
CONCLUSION
Significant correlation between IL-6 and IMT was reported in patients with MetS. While no significant correlation between IL-10, adiponectin and ghrelin with IMT was observed in metabolic syndrome group.
背景
近期研究已证实炎症因子和代谢综合征（MetS）是重要的心血管疾病（CVD）危险因素。最近，颈动脉内膜中层厚度（IMT）的测量已被用于早期动脉粥样硬化的评估。本研究旨在评估伊斯法罕省队列样本中患有和未患有MetS的人群中IMT与一些炎症生物标志物、胃饥饿素和脂联素之间的相关性。
方法
通过随机抽样，从伊斯法罕队列研究（ICS）的参与者中选取88名参与者，并将其分为病例组（患有MetS）和对照组（未患有MetS）。为所有参与者完成了一份包括人口统计学数据和CVD危险因素的问卷。对所有受试者进行了体格检查以及血压、身高、体重和腰围测量。进行血管超声心动图检查以评估双侧各颈动脉的IMT。使用酶联免疫吸附测定（ELISA）法测量白细胞介素-6（IL-6）、白细胞介素-10（IL-10）、高敏C反应蛋白（hs-CRP）、胃饥饿素和脂联素水平。数据录入SPSS（15）软件，并通过t检验、卡方检验、Pearson相关性分析和线性回归分析进行分析。
结果
患有MetS的参与者的平均腰围、体重指数、收缩压、舒张压、hs-CRP和左颈动脉IMT显著更高。所有患者的左颈动脉IMT与IL-6水平之间存在显著相关性（P = 0.03）。在调整年龄和性别后，仅在患有MetS的组中报告了左IMT与IL-6之间的显著关系（P = 0.02）。患有和未患有MetS的受试者中，IMT与其他炎症标志物之间均无关联。
结论
在患有MetS的患者中，报告了IL-6与IMT之间存在显著相关性。而在代谢综合征组中，未观察到IL-10、脂联素和胃饥饿素与IMT之间存在显著相关性。
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