Hwang Young-Hwan, Son Min-Jeong, Yang Jaeseok, Kim Kiwon, Chung Wookyung, Joo Kwon-Wook, Kim Yonsu, Ahn Curie, Oh Kook-Hwan
Department of Internal Medicine, Eulji General Hospital, and Seoul National University, Seoul, Korea.
Perit Dial Int. 2009 Jan-Feb;29(1):81-8.
To study the genetic effects of various inflammatory cytokines on peritoneal solute transport rate (PSTR) in incident Korean peritoneal dialysis (PD) patients.
Case-control association study.
132 patients with baseline peritoneal equilibration test within 1-3 months after starting PD were enrolled. We analyzed the influence of single nucleotide polymorphisms (SNPs) of interleukin-6 (IL-6; -572G/C, T15A), tumor necrosis factor-alpha (TNF-alpha; -1031C/T, -863C/A, -308G/A), and IL-10 (-1082A/G, -592A/C) on baseline PSTR. Clinical parameters such as age, gender, presence of diabetes mellitus, comorbidity, C-reactive protein, and residual renal function were also included as covariates.
The T15A SNP of IL-6 (rs13306435) was associated with PSTR. Patients with TA genotype (n=18) had significantly lower D4/P creatinine (0.65+/-0.087 vs 0.73+/-0.110, p=0.0046) and higher D4/D0 glucose (0.39+/-0.174 vs 0.31+/-0.119, p=0.027) than patients with TT genotype (n=114). The log value of the dialysate appearance rate of IL-6 had a strong positive correlation with D4/P creatinine (r2=0.1294, p<0.0001) and was significantly lower in the TA genotype than the TT genotype (201.7+/-14.42 vs 116.8+/-88.91 pg/minute, p=0.0358). By multiple logistic regression, TA genotype was negatively associated with a higher PSTR (high or high average; odds ratio 0.18; 95% confidence interval 0.048-0.666).
In incident Korean PD patients, T15A polymorphism of IL-6 is associated with dialysate IL-6 concentration and baseline PSTR.
研究多种炎性细胞因子对初发韩国腹膜透析（PD）患者腹膜溶质转运率（PSTR）的遗传效应。
病例对照关联研究。
纳入132例在开始PD后1 - 3个月内进行基线腹膜平衡试验的患者。我们分析了白细胞介素-6（IL-6；-572G/C、T15A）、肿瘤坏死因子-α（TNF-α；-1031C/T、-863C/A、-308G/A）和IL-10（-1082A/G、-592A/C）的单核苷酸多态性（SNP）对基线PSTR的影响。年龄、性别、糖尿病的存在、合并症、C反应蛋白和残余肾功能等临床参数也作为协变量纳入。
IL-6的T15A SNP（rs13306435）与PSTR相关。TA基因型患者（n = 18）的D4/P肌酐显著低于TT基因型患者（n = 114）（0.65±0.087 vs 0.73±0.110，p = 0.0046），D4/D0葡萄糖则显著高于TT基因型患者（0.39±0.174 vs 0.31±0.119，p = 0.027）。IL-6透析液出现率的对数值与D4/P肌酐呈强正相关（r2 = 0.1294，p < 0.0001），且TA基因型显著低于TT基因型（201.7±14.42 vs 116.8±88.91 pg/分钟，p = 0.0358）。通过多因素逻辑回归分析，TA基因型与较高的PSTR（高或高平均；比值比0.18；95%置信区间0.048 - 0.666）呈负相关。
在初发韩国PD患者中，IL-6的T15A多态性与透析液IL-6浓度和基线PSTR相关。
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