From the Department of Radiology (K.M.E.M., F.G., M.H.L.), Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands.
Department of Neonatology (L.S.D.V.), Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands.
AJNR Am J Neuroradiol. 2022 Jun;43(6):802-812. doi: 10.3174/ajnr.A7463. Epub 2022 Apr 29.
Despite their small size, the mammillary bodies play an important role in supporting recollective memory. However, they have typically been overlooked when assessing neurologic conditions that present with memory impairment. While there is increasing evidence of mammillary body involvement in a wide range of neurologic disorders in adults, very little attention has been given to infants and children. Literature searches of PubMed and EMBASE were performed to identify articles that describe mammillary body pathology on brain MR imaging in children. Mammillary body pathology is present in the pediatric population in several conditions, indicated by signal change and/or atrophy on MR imaging. The main causes of mammillary body pathology are thiamine deficiency, hypoxia-ischemia, direct damage due to masses or hydrocephalus, or deafferentation resulting from pathology within the wider Papez circuit. Optimizing scanning protocols and assessing mammillary body status as a standard procedure are critical, given their role in memory processes.
尽管体积小，杏仁体在支持回忆性记忆方面发挥着重要作用。然而，在评估以记忆障碍为表现的神经状况时，它们通常被忽视。尽管越来越多的证据表明杏仁体参与了成人的各种神经疾病，但对婴儿和儿童的关注却很少。对 PubMed 和 EMBASE 进行文献检索，以确定描述儿童脑磁共振成像上杏仁体病理的文章。在几种情况下，儿科人群中存在杏仁体病变，表现为磁共振成像上的信号改变和/或萎缩。杏仁体病变的主要原因是硫胺素缺乏、缺氧缺血、肿块或脑积水直接损伤，或更广泛的帕佩兹回路内的病变导致的去传入。鉴于其在记忆过程中的作用，优化扫描方案并将杏仁体状况评估作为标准程序非常重要。
