影响脑心肌炎病毒病毒粒子组成和热稳定性的因素。
Factors affecting composition and thermostability of mengovirus virions.
作者信息
Bond C W, Swim H E
出版信息
J Virol. 1977 Mar;21(3):1256-61. doi: 10.1128/JVI.21.3.1256-1261.1977.
Abstract
The composition of mengovirus virions produced by infected cells varies with the incubation temperature. Virons produced at 37.0 or 39.5 degrees contain four major polypeptides (alpha, beta, gamma, and delta) and one minor polypeptide (beta'). Virons produced at 31.5 degrees C contain two additional polypeptides (D1 and E). The virions of two temperature-sensitive (ts) and thermolabile mutants of mengovirus (ts25 and ts88) contain an increased amount of polypeptide beta', with a corresponding decrease in polypeptide beta when compared with the wild-type mengovirus.
摘要
受感染细胞产生的脑心肌炎病毒粒子的组成随培养温度而变化。在37.0或39.5摄氏度产生的病毒粒子含有四种主要多肽（α、β、γ和δ）和一种次要多肽（β'）。在31.5摄氏度产生的病毒粒子含有另外两种多肽（D1和E）。与野生型脑心肌炎病毒相比，脑心肌炎病毒的两个温度敏感（ts）和热不稳定突变体（ts25和ts88）的病毒粒子含有增加量的多肽β'，同时多肽β相应减少。
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