芋螺毒素的结构研究。

Structural studies of conotoxins.

作者信息

Daly Norelle L, Craik David J

机构信息

The University of Queensland, Institute for Molecular Bioscience and Australian Research Council Special Research Centre for Functional and Applied Genomics, Brisbane, QLD, Australia.

出版信息

IUBMB Life. 2009 Feb;61(2):144-50. doi: 10.1002/iub.158.

DOI:10.1002/iub.158

PMID:19165896

Abstract

Conotoxins are small disulfide-rich peptides from the venoms of marine cone snails. They target a variety of ion channels, transporters, and receptors besides the interest in their natural functions in venoms and they are of much interest as drug leads. This short article gives an overview of the structural diversity of conotoxins, and illustrates this diversity with recent selected examples of conotoxin structures.

摘要

芋螺毒素是来自海洋芋螺毒液的富含二硫键的小肽。除了对其在毒液中的天然功能感兴趣外，它们还作用于多种离子通道、转运体和受体，并且作为药物先导物备受关注。这篇短文概述了芋螺毒素的结构多样性，并用最近选定的芋螺毒素结构实例来说明这种多样性。