伊朗伊斯兰共和国哈马丹2005年霍乱疫情中霍乱患者抗菌谱测试调查

Survey of antibiogram tests in cholera patients in the 2005 epidemic in Hamadan, Islamic Republic of Iran.

作者信息

Keramat F, Hashemi S H, Mamani M, Ranjbar M, Erfan H

机构信息

Department of Infectious Diseases, Sina Hospital, Hamadan University of Medical Sciences, Hamadan, Islamic Republic of Iran.

出版信息

East Mediterr Health J. 2008 Jul-Aug;14(4):768-75.

PMID:19166158

Abstract

An analytical cross-sectional study determined the serogroups and serotypes of Vibrio cholerae, and their antibiotic resistance rates, in the 2005 cholera epidemic in Hamadan. All 190 patients with positive stool cultures had V. cholerae serogroup O1, biotype El Tor and serotype Inaba positive. Of 60 cases selected randomly for antibiogram testing, sensitivity to norfloxacin, ciprofloxacin, kanamycin, amikacin, tetracycline and doxycycline was 97%, 92%, 88%, 85%, 77% and 67% respectively. Resistance to furazolidone, trimethoprim-sulfamethoxazole and erythromycin was 100%, 98% and 62% respectively. Comparison with the results of the 1998 epidemic suggests a worrying increase in the resistance of V. cholerae to erythromycin, doxycycline and ciprofloxacin.

摘要

一项分析性横断面研究确定了2005年哈马丹霍乱疫情中霍乱弧菌的血清群和血清型及其抗生素耐药率。所有190例粪便培养呈阳性的患者霍乱弧菌血清群O1、生物型埃尔托型和血清型稻叶型均呈阳性。在随机选择进行药敏试验的60例病例中，对诺氟沙星、环丙沙星、卡那霉素、阿米卡星、四环素和强力霉素的敏感性分别为97%、92%、88%、85%、77%和67%。对呋喃唑酮、甲氧苄啶-磺胺甲恶唑和红霉素的耐药率分别为100%、98%和62%。与1998年疫情结果相比，霍乱弧菌对红霉素、强力霉素和环丙沙星的耐药性令人担忧地增加。