Parham D M, Morton K, Robertson A J, Philip W D
Department of Pathology, Ninewells Hospital and Medical School, Dundee, Scotland, UK.
Histopathology. 1991 Sep;19(3):263-8. doi: 10.1111/j.1365-2559.1991.tb00032.x.
We describe the changing phenotypic appearance over a 7-year period of a malignant neoplasm of the vulva. This lesion was studied by light and electronmicroscopy and immunohistochemical techniques. The tumour contained both carcinomatous and sarcomatous elements including osteosarcomatous differentiation. To our knowledge osteosarcomatous differentiation has not been reported previously at this site. We submit that the best term for this type of neoplasm, based on tumour differentiation rather than reputed histogenesis, is carcinosarcoma. Tumours such as these occurring in the female genital tract should be distinguished from metastatic mixed Müllerian tumours.
我们描述了一例外阴恶性肿瘤在7年期间不断变化的表型外观。通过光镜、电镜及免疫组化技术对该病变进行了研究。肿瘤包含癌性和肉瘤性成分，包括骨肉瘤分化。据我们所知，该部位此前尚未有骨肉瘤分化的报道。我们认为，基于肿瘤分化而非所谓的组织发生，这类肿瘤的最佳术语是癌肉瘤。发生在女性生殖道的此类肿瘤应与转移性混合性苗勒管肿瘤相鉴别。
