Department of Oncology, Catholic University, Campobasso, Italy.
Diagn Pathol. 2011 Oct 1;6:95. doi: 10.1186/1746-1596-6-95.
Vulvar squamous cell carcinoma with sarcoma-like stroma represents an extremely rare histological entity showing the co-existence of both epithelial and mesenchymal features: these tumors, firstly described in the skin by Martin and Stewart in 1935 have been further described in other anatomic sites including oral cavity, larynx, breast, lung and oesophagus. The complexity of the histology, as well as its aggressive clinical behaviour makes the diagnosis and the exploitment of effective therapeutic approaches very difficult, so that no definitive guidelines for treatments are currently available. Here, we describe a case of advanced stage vulvar squamous cell carcinoma with sarcoma-like stroma showing an unfavourable prognosis despite the use of an aggressive multimodal approach. A revision of the currently published cases have been also provided.
外阴鳞状细胞癌伴肉瘤样间质是一种极为罕见的组织学实体，表现为上皮和间叶特征的共存：这些肿瘤首先由 Martin 和 Stewart 于 1935 年在皮肤中描述，随后在其他解剖部位如口腔、喉、乳腺、肺和食管中进一步描述。其组织学的复杂性以及侵袭性的临床行为使得诊断和制定有效的治疗方法非常困难，因此目前尚无针对该疾病的明确治疗指南。在这里，我们描述了一例晚期外阴鳞状细胞癌伴肉瘤样间质的病例，尽管采用了积极的多模式治疗方法，但预后仍不佳。还对目前已发表的病例进行了回顾。
