Marcos-Atxutegi C, Gandolfi B, Arangüena T, Sepúlveda R, Arévalo M, Simón F
Laboratorio de Parasitología, Facultad de Farmacia, Universidad de Salamanca, Spain.
Vet Parasitol. 2009 Apr 6;161(1-2):69-75. doi: 10.1016/j.vetpar.2008.12.011. Epub 2008 Dec 24.
Ascaridia galli, an intestinal nematode that affects hens and other domestic and wild birds, causes economic losses in avian exploitations. The present work shows that A. galli stimulates a strong antibody response as well as an intense inflammatory reaction, in the intestinal mucous of experimentally infected Lohmann Brown laying hens. IgG antibodies against soluble extracts of A. galli embrionated eggs and adult worms, were detected in both blood and yolks eggs from infected hens during a period of 105 days after the infection. This indicates that hens transfer to their offspring a part of the IgG antibodies produced when they become infected. The antigens responsible for the stimulation of specific IgG were molecules of 30-34, 44-54 and 58-90 kDa, while in the yolk eggs of infected hens a reactivity directed against antigens of molecular weight (M(w)) lower than 50 kDa was detected. Histology revealed traumatic lesions with leukocyte infiltration, and inflammation of the intestinal wall of the infected hens after 105 days of initial infection. The possible influence of the immune and inflammatory response on the population dynamics of the parasite is discussed.
鸡蛔虫是一种影响母鸡以及其他家养和野生禽类的肠道线虫，会给禽类养殖带来经济损失。目前的研究表明，在实验感染的罗曼褐蛋鸡的肠道黏液中，鸡蛔虫会引发强烈的抗体反应以及剧烈的炎症反应。在感染后的105天内，从感染母鸡的血液和蛋黄中均检测到了针对鸡蛔虫胚胎卵和成虫可溶性提取物的IgG抗体。这表明母鸡在感染后会将产生的一部分IgG抗体传递给后代。刺激产生特异性IgG的抗原是分子量为30 - 34、44 - 54和58 - 90 kDa的分子，而在感染母鸡的蛋黄中检测到了针对分子量低于50 kDa抗原的反应性。组织学检查显示，在初次感染105天后，感染母鸡的肠道出现了伴有白细胞浸润的创伤性病变以及肠壁炎症。文中还讨论了免疫和炎症反应对寄生虫种群动态的可能影响。
