Fasullo Matthew J, Al-Azzawi Yasir, Abergel Jeffrey
Department of Medicine, University of Massachusetts Medical Center, Worcester, MA.
Department of Gastroenterology, University of Massachusetts Medical Center, Worcester, MA.
ACG Case Rep J. 2017 Jul 19;4:e87. doi: 10.14309/crj.2017.87. eCollection 2017.
Microscopic colitis (MC) is an inflammatory condition of the large bowel that is associated with chronic, nonbloody diarrhea. Colonoscopy usually demonstrates normal mucosa, while tissue biopsy reveals intraepithelial lymphocytes or a subepithelial collagen band. Although no specific antibody has been discovered, MC is associated with several autoimmune disorders such as celiac disease, Hashimoto's thyroiditis, and rheumatoid arthritis. There are only a small number of case reports documenting possible hereditary MC cases, but up to 12% of patients with MC have a family history of inflammatory bowel disease. Other associations include proton pump inhibitor use, cigarette smoking, HLA-DQ2/86, and possibly some gastrointestinal infections.
显微镜下结肠炎（MC）是一种大肠的炎症性疾病，与慢性非血性腹泻有关。结肠镜检查通常显示黏膜正常，而组织活检显示上皮内淋巴细胞或上皮下胶原带。虽然尚未发现特异性抗体，但MC与多种自身免疫性疾病相关，如乳糜泻、桥本甲状腺炎和类风湿性关节炎。仅有少数病例报告记录了可能的遗传性MC病例，但高达12%的MC患者有炎症性肠病家族史。其他相关因素包括使用质子泵抑制剂、吸烟、HLA-DQ2/86，以及可能的一些胃肠道感染。
