Nguyen C, Ho K C, Haughton V M
Department of Radiology, Medical College of Wisconsin, Milwaukee.
Invest Radiol. 1991 Aug;26(8):745-7. doi: 10.1097/00004424-199108000-00010.
Arachnoiditis has been reported in patients who had received previous epidural injections of anesthetic agents. The purpose of this study was to determine if epidural injections of lidocaine are sufficient to cause arachnoiditis. Four monkeys that received a single epidural injection of lidocaine hydrochloride 1% were compared to four controls that had epidural injections of 0.9% saline. Four dogs that had multiple epidural injections of lidocaine hydrochloride 1% were compared to four controls that had multiple injections of saline. All animals were killed on the eighty-fourth day of the experiment. The dural sac, containing nerve roots and spinal cord, was removed intact from the lumbar spinal canal, fixed, sectioned, stained, and examined microscopically for evidence of arachnoid inflammation and fibrosis. No significant changes were found in the treated animals. Lidocaine hydrochloride 1% injected singly or repeatedly in the epidural space does not appear to be a cause of significant chronic meningeal reaction.
蛛网膜膜炎曾在接受过硬膜外注射麻醉剂的患者中被报道。本研究的目的是确定硬膜外注射利多卡因是否足以引起蛛网膜膜炎。将4只接受单次硬膜外注射1%盐酸利多卡因的猴子与4只接受硬膜外注射0.9%生理盐水的对照猴子进行比较。将4只接受多次硬膜外注射1%盐酸利多卡因的狗与4只接受多次生理盐水注射的对照狗进行比较。所有动物在实验的第84天被处死。将包含神经根和脊髓的硬膜囊完整地从腰段椎管中取出，固定、切片、染色，并进行显微镜检查以寻找蛛网膜炎症和纤维化的证据。在接受治疗的动物中未发现显著变化。单次或重复在硬膜外间隙注射1%盐酸利多卡因似乎不是引起显著慢性脑膜反应的原因。
