Haughton V M, Nguyen C M, Ho K C
Department of Radiology, Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, Milwaukee 53226.
Radiology. 1988 Nov;169(2):475-8. doi: 10.1148/radiology.169.2.3174996.
The effect of chymopapain and contrast media in the epidural space on meninges has not been studied conclusively. The authors injected chymopapain into the epidural space of monkeys and measured the degree of arachnoid fibrosis that resulted. Animals were given injections of 1.2 mL of diatrizoate (280 mg iodine per milliliter), chymopapain (100 IU/mL), kaolin (100 mg/mL) (as a positive control), or saline (0.9%) (as a negative control). Three months later the animals were killed; the dural sac was removed intact and was fixed, sectioned, stained, and examined with light microscopy. Kaolin-treated animals developed mild to marked fibrosis of the dura. The saline- and diatrizoate-treated animals developed little or no evidence of fibrosis. One of four chymopapain-treated animals developed degenerative changes in dorsal nerve roots and fibrosis in the adjacent arachnoid. The other chymopapain-treated animals had little or no evidence of fibrosis. The studies suggest that neither diatrizoate nor chymopapain causes arachnoid fibrosis.
糜蛋白酶和硬膜外腔造影剂对脑脊膜的影响尚未得到最终研究结论。作者将糜蛋白酶注入猴子的硬膜外腔，并测量由此导致的蛛网膜纤维化程度。给动物注射1.2毫升泛影葡胺（每毫升含280毫克碘）、糜蛋白酶（100国际单位/毫升）、高岭土（100毫克/毫升）（作为阳性对照）或生理盐水（0.9%）（作为阴性对照）。三个月后处死动物；完整取出硬脊膜囊并固定、切片、染色，然后用光学显微镜检查。高岭土处理的动物出现了轻度至明显的硬脑膜纤维化。生理盐水和泛影葡胺处理的动物几乎没有或没有纤维化迹象。四只接受糜蛋白酶处理的动物中有一只在背神经根出现退行性改变，相邻蛛网膜出现纤维化。其他接受糜蛋白酶处理的动物几乎没有或没有纤维化迹象。研究表明，泛影葡胺和糜蛋白酶均不会导致蛛网膜纤维化。
