Brenn S H, Couto S S, Craft D M, Leung C, Bergman P J
Donaldson-Atwood Cancer Clinic, The Animal Medical Center, New York, NY, USA.
Vet Comp Oncol. 2008 Sep;6(3):201-11. doi: 10.1111/j.1476-5829.2008.00161.x.
P-glycoprotein (Pgp) is a transmembrane protein pump involved in drug resistance in canine and human lymphoma. There are no published clinical studies evaluating Pgp expression in feline lymphoma. The purpose of this study is to evaluate the level of Pgp expression in feline lymphoma and correlate it with clinical outcome. Two human Pgp monoclonal antibodies, C219 and C494, were used to detect Pgp expression in tissue samples from 63 cats with lymphoma. Demographic results appear comparable to recently published feline lymphoma studies. The Kaplan-Meier median remission and survival times were 164 and 571 days, respectively. Fourteen cats had positive expression of Pgp using MAb C219, and 40 were positive with C494. Variables statistically associated with survival included bone marrow involvement, stage, substage, and use of radiation therapy as a part of treatment. Pgp expression as assessed by MAb C219 and C494 is not predictive of remission or survival time in cats with lymphoma.
P-糖蛋白（Pgp）是一种跨膜蛋白泵，与犬类和人类淋巴瘤的耐药性有关。目前尚无关于评估猫淋巴瘤中Pgp表达的已发表临床研究。本研究的目的是评估猫淋巴瘤中Pgp的表达水平，并将其与临床结果相关联。使用两种人Pgp单克隆抗体C219和C494检测63只患有淋巴瘤的猫的组织样本中的Pgp表达。人口统计学结果与最近发表的猫淋巴瘤研究结果相当。Kaplan-Meier中位缓解期和生存期分别为164天和571天。使用单克隆抗体C219，14只猫的Pgp表达呈阳性，使用C494时40只呈阳性。与生存统计学相关的变量包括骨髓受累、分期、亚分期以及作为治疗一部分使用放射治疗。通过单克隆抗体C219和C494评估的Pgp表达不能预测猫淋巴瘤的缓解期或生存时间。
