支持枇杷种子提取物抑制肥大细胞活化的动物研究。
Animal studies supporting the inhibition of mast cell activation by Eriobotrya japonica seed extract.
作者信息
Onogawa Masahide, Sun Guangchen, Takuma Daisuke, Hamada Atsuhide, Yokota Junko, Yoshioka Saburo, Kusunose Masahiko, Miyamura Mitsuhiko, Kyotani Shojiro, Nishioka Yutaka
机构信息
Department of Biomedical Science, Kochi Medical Graduate School, Kochi, Japan.
出版信息
J Pharm Pharmacol. 2009 Feb;61(2):237-41. doi: 10.1211/jpp/61.02.0014.
OBJECTIVES
The potent antioxidant activity of Eriobotrya japonica seed extract (ESE) and its usefulness in the prevention and treatment of various disorders has been reported previously. Its antioxidant activity associated with beta-sitosterol and polyphenols contained in the extract was also validated. In this study, anti-allergic activity of Eriobotrya japonica seed extract was investigated.
METHODS
The inhibition of histamine release-mediated type 1 allergy by Eriobotrya japonica seed extract was used as an index.
KEY FINDINGS
The administration of this extract inhibited histamine release from rat mast cells, suggesting its usefulness in allergic disease treatment. In an experiment using a guinea-pig allergic rhinitis model, this extract reduced the frequency of sneezing and nose-scratching.
CONCLUSIONS
These results suggest that Eriobotrya japonica seed extract may contribute to the relief of allergic disease-related symptoms.
目的
先前已有报道称枇杷种子提取物（ESE）具有强大的抗氧化活性及其在预防和治疗各种疾病方面的效用。提取物中所含的β-谷甾醇和多酚类物质与其抗氧化活性的关联也得到了验证。在本研究中，对枇杷种子提取物的抗过敏活性进行了研究。
方法
以枇杷种子提取物对组胺释放介导的Ⅰ型过敏的抑制作用作为指标。
主要发现
给予该提取物可抑制大鼠肥大细胞释放组胺，表明其在过敏性疾病治疗中具有效用。在使用豚鼠过敏性鼻炎模型的实验中，该提取物降低了打喷嚏和挠鼻的频率。
结论
这些结果表明，枇杷种子提取物可能有助于缓解过敏性疾病相关症状。
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