Garrido Marta I, Kilner James M, Stephan Klaas E, Friston Karl J
Wellcome Trust Centre for Neuroimaging, University College London, UK.
Clin Neurophysiol. 2009 Mar;120(3):453-63. doi: 10.1016/j.clinph.2008.11.029. Epub 2009 Jan 31.
The mismatch negativity (MMN) is a brain response to violations of a rule, established by a sequence of sensory stimuli (typically in the auditory domain) [Näätänen R. Attention and brain function. Hillsdale, NJ: Lawrence Erlbaum; 1992]. The MMN reflects the brain's ability to perform automatic comparisons between consecutive stimuli and provides an electrophysiological index of sensory learning and perceptual accuracy. Although the MMN has been studied extensively, the neurophysiological mechanisms underlying the MMN are not well understood. Several hypotheses have been put forward to explain the generation of the MMN; amongst these accounts, the "adaptation hypothesis" and the "model adjustment hypothesis" have received the most attention. This paper presents a review of studies that focus on neuronal mechanisms underlying the MMN generation, discusses the two major explanatory hypotheses, and proposes predictive coding as a general framework that attempts to unify both.
失匹配负波（MMN）是大脑对违反由一系列感觉刺激（通常在听觉领域）所建立规则的反应 [纳塔宁 R. 注意力与大脑功能。新泽西州希尔斯代尔：劳伦斯·埃尔拉姆博出版社；1992年]。MMN反映了大脑在连续刺激之间进行自动比较的能力，并提供了感觉学习和感知准确性的电生理指标。尽管对MMN已经进行了广泛研究，但其潜在的神经生理机制尚未得到很好的理解。已经提出了几种假说来解释MMN的产生；在这些解释中，“适应假说”和“模型调整假说”受到了最多关注。本文对聚焦于MMN产生的神经元机制的研究进行了综述，讨论了这两种主要的解释性假说，并提出预测编码作为一个试图统一两者的通用框架。
