Check J H, Nowroozi K, Check M L, Vetter B
University of Medicine and Dentistry of New Jersey, Robert Wood Johnston Medical School, Camden.
Hum Reprod. 1991 Apr;6(4):511-4. doi: 10.1093/oxfordjournals.humrep.a137369.
The progestagen-associated endometrial protein (PEP) level rises from the early to the late luteal phase. A study was performed in infertile women where late luteal phase endometrial biopsies and serum PEP levels were obtained. The objective of the study was to evaluate the correlation between the PEP levels and the endometrial biopsies and to determine if subnormal PEP levels could be improved by the same therapies used to correct endometrial defects. There was a poor correlation between PEP levels and endometrial biopsies (r = 0.17). Similarly, there was no significant correlation between PEP levels and levels of the following hormones: mid- and late-luteal phase progesterone (P) (r = 0.186 and 0.282 respectively), mid-luteal phase 17-hydroxyprogesterone (17-OHP) (r = 0.139) and mid-luteal phase oestradiol (r = 0.135). Furthermore, there was no correlation between PEP levels and the dosage of progesterone used in therapy (r = 0.07). There were no statistically significant differences in PEP values (U/ml) depending on whether any fertility drug was taken. Thus our data suggest that progesterone may only have a permissive role, with some other factor(s) controlling the actual rise and fall of PEP.
孕激素相关子宫内膜蛋白（PEP）水平从黄体期早期到晚期逐渐升高。一项针对不孕女性的研究获取了她们黄体期晚期的子宫内膜活检样本及血清PEP水平。该研究的目的是评估PEP水平与子宫内膜活检之间的相关性，并确定用于纠正子宫内膜缺陷的相同疗法是否能改善PEP水平低于正常的情况。PEP水平与子宫内膜活检之间的相关性较差（r = 0.17）。同样，PEP水平与以下激素水平之间也无显著相关性：黄体期中期和晚期的孕酮（P）（分别为r = 0.186和0.282）、黄体期中期的17-羟孕酮（17-OHP）（r = 0.139）以及黄体期中期的雌二醇（r = 0.135）。此外，PEP水平与治疗中使用的孕酮剂量之间也无相关性（r = 0.07）。无论是否服用任何生育药物，PEP值（U/ml）均无统计学上的显著差异。因此，我们的数据表明，孕酮可能仅起允许作用，PEP的实际升降受其他某些因素控制。
