McRae M A, Galle P C, Joshi S G
Department of Obstetrics and Gynecology, Southern Illinois University School of Medicine, Springfield 62794-9230.
Hum Reprod. 1991 Jul;6(6):761-5. doi: 10.1093/oxfordjournals.humrep.a137424.
Late secretory endometrium synthesizes and secretes progestagen-associated endometrial protein (PEP), which is measurable in the serum of cycling women, and has been shown to increase in concentration during the luteal phase of the normal menstrual cycle. The purpose of this study was to determine the utility of serum PEP as a predictor of normal or inadequate luteal phase endometrial differentiation. One-hundred-and-twenty-five endometrial biopsies were taken within 4 days of a subsequent menstrual period, during the course of evaluation of infertility or recurrent abortion. Twenty-one of these biopsies demonstrated glandular/stromal asynchrony. Thirteen patients exhibited 'out-of-phase' endometrial biopsies and 91 patients had 'in-phase' biopsies. Mean PEP values significantly increased from the mid-luteal phase to the late luteal phase. Mean PEP values for patients with in-phase biopsies (43.92 units/ml) were not significantly different from those with out-of-phase biopsies (25.24 units/ml, P = 0.0942). PEP values for patients with asynchronous biopsies were intermediate. Use of clomiphene citrate did not affect these results.
分泌晚期子宫内膜合成并分泌孕激素相关子宫内膜蛋白（PEP），该蛋白可在处于月经周期的女性血清中检测到，并且已证实在正常月经周期的黄体期其浓度会升高。本研究的目的是确定血清PEP作为黄体期子宫内膜正常分化或分化不足预测指标的效用。在评估不孕症或复发性流产的过程中，于随后月经周期的4天内获取了125份子宫内膜活检样本。其中21份活检样本显示存在腺上皮/间质不同步。13例患者的子宫内膜活检显示“不同步”，91例患者的活检显示“同步”。PEP的平均数值从黄体中期到黄体晚期显著升高。活检显示同步的患者的PEP平均数值（43.92单位/毫升）与活检显示不同步的患者（25.24单位/毫升，P = 0.0942）相比无显著差异。活检显示不同步的患者的PEP数值处于中间水平。使用枸橼酸氯米芬不影响这些结果。
