Joshi S G, Rao R, Henriques E E, Raikar R S, Gordon M
J Clin Endocrinol Metab. 1986 Nov;63(5):1247-9. doi: 10.1210/jcem-63-5-1247.
We previously demonstrated that the human endometrium synthesizes and secretes a specific protein designated "Progestagen-associated Endometrial Protein" or PEP. This work was undertaken to determine luteal phase levels of PEP in serum of cycling women with histologic evidence of adequate endometrium (endometrium in phase) or inadequate endometrium (endometrium out of phase by 3-4 days). The results provide a normative curve with 95% confidence limits for serum PEP concentrations vs normalized cycle day in women with adequate endometrium (judged by histologic endometrial dating), and indicate that the PEP concentration increases exponentially after day 22, with a mean doubling time of 2.95 +/- 1.60 (mean +/- SD) days (based on serial data from 13 women). More importantly, the proportion of serum PEP values falling outside of the 95% confidence limits was significantly greater (p less than 0.001) in women with inadequate endometrium (83%) than in women with adequate endometrium (16%). Therefore, determination of PEP in serum, rather than the more invasive endometrial biopsy examination, may serve as a method of choice for evaluating endometrial adequacy in infertile women.
我们先前证明，人类子宫内膜可合成并分泌一种特定蛋白质，命名为“孕激素相关子宫内膜蛋白”（PEP）。本研究旨在测定月经周期正常、子宫内膜组织学证据显示正常（处于相应阶段的子宫内膜）或异常（子宫内膜落后3 - 4天）的女性血清中PEP的黄体期水平。结果提供了一条正常曲线，给出了具有正常子宫内膜（通过组织学子宫内膜分期判断）的女性血清PEP浓度相对于标准化月经周期日的95%置信区间，并表明在第22天之后，PEP浓度呈指数增加，平均倍增时间为2.95±1.60（平均值±标准差）天（基于13名女性的系列数据）。更重要的是，子宫内膜异常的女性（83%）血清PEP值超出95%置信区间的比例显著高于子宫内膜正常的女性（16%）（p<0.001）。因此，测定血清中的PEP，而非更具侵入性的子宫内膜活检检查，可能成为评估不孕女性子宫内膜是否正常的首选方法。
