实验性变应性神经炎中活化的T淋巴细胞亚群

Activated T lymphocyte subsets in experimental allergic neuritis.

作者信息

Hamaguchi K, Ohno R, Tsuji T, Yamashita T, Negishi T, Nomura K, Hosokawa T

机构信息

Department of Neurology, Saitama Medical School, Japan.

出版信息

J Neuroimmunol. 1991 Nov;34(2-3):191-6. doi: 10.1016/0165-5728(91)90129-u.

DOI:10.1016/0165-5728(91)90129-u

PMID:1918325

Abstract

Changes in activated T cell subsets in peripheral blood were examined during the course of experimental allergic neuritis (EAN), using two-color immunofluorescence flow cytometry. Both CD4+ and CD8+ activated T cells decreased transiently before the onset of clinical signs, and increased just around the time of onset of the disease. In contrast, during the recovery phase, the numbers of CD4+ activated T cells returned to the normal range, whereas CD8+ activated T cells continued to increase. These findings imply that activation of CD4+ helper/inducer cells contributes mainly to the evolution of EAN, and that of CD8+ suppressor cells are necessary for recovery.

摘要

利用双色免疫荧光流式细胞术，在实验性变应性神经炎（EAN）病程中检测外周血中活化T细胞亚群的变化。CD4⁺和CD8⁺活化T细胞在临床症状出现前均短暂减少，而在疾病发作时前后增加。相比之下，在恢复阶段，CD4⁺活化T细胞数量恢复到正常范围，而CD8⁺活化T细胞持续增加。这些发现提示，CD4⁺辅助/诱导细胞的活化主要促成EAN的进展，而CD8⁺抑制细胞的活化对恢复是必需的。