Patel Rajan S, Clark Jonathan R, Dirven Richard, Wyten Rebecca, Gao Kan, O'Brien Christopher J
Sydney Head and Neck Cancer Institute, Sydney Cancer Centre, Royal Prince Alfred Hospital, University of Sydney, Sydney, New South Wales, Australia.
ANZ J Surg. 2009 Jan-Feb;79(1-2):19-22. doi: 10.1111/j.1445-2197.2008.04791.x.
The aim of the study was to analyse the clinical outcome of patients treated surgically for oral carcinoma. A retrospective cohort study was undertaken of 356 patients with oral cavity cancer whose clinicopathological information had been collected prospectively onto a dedicated head and neck database. Disease recurrence and survival were assessed. Neck metastases occurred in 42% of patients. Tumour thickness (both 2 and 5 mm) predicted the presence of nodal metastases. Both pathological T stage (P < 0.001) and tumour thickness cut-off of 5 mm (P = 0.03) were independent predictors of disease-specific survival. With a median follow up of 41 months, overall survival at 5 years was 59% and disease-specific survival was 73%. Patients with thick tumours have a high risk of nodal metastases and this supports the liberal use of elective selective neck dissection in patients with clinically negative necks.
本研究的目的是分析接受口腔癌手术治疗患者的临床结局。对356例口腔癌患者进行了一项回顾性队列研究，这些患者的临床病理信息已前瞻性地收集到一个专门的头颈数据库中。评估了疾病复发和生存率。42%的患者发生颈部转移。肿瘤厚度（2mm和5mm）可预测淋巴结转移的存在。病理T分期（P<0.001）和5mm的肿瘤厚度临界值（P = 0.03）都是疾病特异性生存的独立预测因素。中位随访41个月，5年总生存率为59%，疾病特异性生存率为73%。肿瘤厚的患者发生淋巴结转移的风险高，这支持对临床颈部阴性的患者广泛采用选择性颈清扫术。
