丙型肝炎病毒感染模型与肝细胞稳态分析
ANALYSIS OF HEPATITIS C VIRUS INFECTION MODELS WITH HEPATOCYTE HOMEOSTASIS.
作者信息
Reluga Timothy C, Dahari Harel, Perelson Alan S
机构信息
THEORETICAL BIOLOGY AND BIOPHYSICS GROUP, THEORETICAL DIVISION, LOS ALAMOS NATIONAL LABORATORY, LOS ALAMOS, NM 87545.
出版信息
SIAM J Appl Math. 2009 Jan 14;69(4):999-1023. doi: 10.1137/080714579.
Abstract
Recently, we developed a model for hepatitis C virus (HCV) infection that explicitly includes proliferation of infected and uninfected hepatocytes. The model predictions agree with a large body of experimental observations on the kinetics of HCV RNA change during acute infection, under antiviral therapy, and after the cessation of therapy. Here we mathematically analyze and characterize both the steady state and dynamical behavior of this model. The analyses presented here are important not only for HCV infection but should also be relevant for modeling other infections with hepatotropic viruses, such as hepatitis B virus.
摘要
最近，我们开发了一种丙型肝炎病毒（HCV）感染模型，该模型明确纳入了受感染和未受感染肝细胞的增殖情况。该模型预测结果与大量关于急性感染期间、抗病毒治疗期间以及治疗停止后HCV RNA变化动力学的实验观察结果相符。在此，我们对该模型的稳态和动力学行为进行数学分析与表征。本文所呈现的分析不仅对HCV感染具有重要意义，对于模拟其他嗜肝病毒（如乙型肝炎病毒）感染也应具有相关性。
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