1,1-二取代烯烃的不对称硼氢化反应。
Asymmetric hydroboration of 1,1-disubstituted alkenes.
作者信息
Thomas Stephen P, Aggarwal Varinder K
机构信息
School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
出版信息
Angew Chem Int Ed Engl. 2009;48(11):1896-8. doi: 10.1002/anie.200805604.
PMID:19185046
Abstract
A breakthrough in the asymmetric hydroboration of notoriously difficult 1,1-disubstituted alkenes using a new family of highly effective hydroboration reagents is described (see scheme). The intermediate boranes can be oxidized to alcohols or used in Suzuki-Miyaura cross-coupling reactions.
摘要
本文描述了使用一类新型高效硼氢化试剂，在对 notoriously difficult 的 1,1-二取代烯烃进行不对称硼氢化反应方面取得的突破（见方案）。中间体硼烷可被氧化为醇类，或用于铃木-宫浦交叉偶联反应。
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