Márquez M T, Ponce-Hornos J E, Aramendía P
Naunyn Schmiedebergs Arch Pharmacol. 1986 Jun;333(2):168-71. doi: 10.1007/BF00506521.
The effects of papaverine upon force of contraction, maximal rate of contraction, maximal rate of relaxation and 45Ca efflux were studied in isolated superfused rat left atria electrically driven at 1 Hz. Papaverine (3 X 10(-5) mol/l, increased developed tension (from 5.35 +/- 1.17 mN to 7.18 +/- 1.51 mN) by 1.8 +/- 0.41 mN (+33%, p less than 0.01) and maximal rate of contraction (+T) by 34.5 +/- 13% (p less than 0.05). In all experimental conditions tested, papaverine increased the rate of 45Ca efflux. The amount by which papaverine increased 45Ca efflux was 175 +/- 41 nmoles . g wet wt-1 and 304 +/- 76 nmoles . g wet wt-1, in the presence and in the absence of caffeine, respectively. The plot of changes in 45Ca efflux versus changes in developed tension fitted to a straight line (r = +0.56, n = 17, p less than 0.05), with a slope and intercept of 42 nmoles Ca . mN-1 . g wet wt-1 and -0.47 mN respectively, suggesting an association between the changes induced by papaverine in force development and increased 45Ca efflux.
在以1Hz频率电驱动的离体灌流大鼠左心房中，研究了罂粟碱对收缩力、最大收缩速率、最大舒张速率和45Ca外流的影响。罂粟碱（3×10(-5)mol/l）使舒张期张力增加（从5.35±1.17mN增加到7.18±1.51mN），增加了1.8±0.41mN（+33%，p<0.01），最大收缩速率（+T）增加了34.5±13%（p<0.05）。在所有测试的实验条件下，罂粟碱均增加了45Ca外流。在存在和不存在咖啡因的情况下，罂粟碱增加45Ca外流的量分别为175±41nmol·g湿重-1和304±76nmol·g湿重-1。45Ca外流变化与舒张期张力变化的关系图拟合为一条直线（r = +0.56，n = 17，p<0.05），斜率和截距分别为42nmol Ca·mN-1·g湿重-1和-0.47mN，表明罂粟碱引起的力发展变化与45Ca外流增加之间存在关联。
