Yadava R L, Rao C K, Thapar B R, Narasimham M V
National Malaria Eradication Programme, Delhi.
J Commun Dis. 1991 Mar;23(1):55-8.
The blood Cholinesterase (ChE) level of malathion in spraymen is continuously monitored through a "built-in warning system" existing under NMEP since the introduction of malathion spraying. The data available from the States of Maharashtra, Punjab and Gujarat revealed that, in spraymen of Punjab, the ChE level in 1988 and 1989 remained normal in about 99.8 per cent spray personnel, and in 1 out of 381 workers, the ChE level fell to 62.5 per cent during 1989. In Gujarat and Maharashtra, the normal level of ChE was maintained in nearly 88 and 98.4 per cent of spray personnel respectively during the spraying period. The ChE level fell to 62.5 per cent in 11.9 per cent of spray staff in Gujarat during 1987 and in 1.5 and 1.6 per cent persons during 1988 and 1989 respectively in Maharashtra. Only in three cases (0.07 per cent) out of 4,100 in Maharashtra showed depression in ChE to 50 per cent in 1988. In none of the above mentioned cases, there was any parasympathetic overstimulation or uneasiness, etc, even then they were withdrawn from spray and were given rest and where needed medical care.
自引入马拉硫磷喷洒作业后，通过国家疟疾根除计划（NMEP）现有的“内置预警系统”，对喷洒人员的血液胆碱酯酶（ChE）水平进行持续监测。来自马哈拉施特拉邦、旁遮普邦和古吉拉特邦的数据显示，旁遮普邦的喷洒人员中，1988年和1989年约99.8%的喷洒人员ChE水平保持正常，在381名工人中有1人在1989年期间ChE水平降至62.5%。在古吉拉特邦和马哈拉施特拉邦，喷洒期间分别有近88%和98.4%的喷洒人员ChE水平维持正常。1987年古吉拉特邦11.9%的喷洒人员ChE水平降至62.5%，1988年和1989年马哈拉施特拉邦分别有1.5%和1.6%的人员ChE水平降至62.5%。1988年马哈拉施特拉邦4100例中只有3例（0.07%）ChE水平降至50%。在上述所有案例中，即使没有任何副交感神经刺激过度或不适等情况，他们也被停止喷洒工作并给予休息，必要时还提供医疗护理。
